Poster Session
Topic 1: Amyotrophic lateral sclerosis (ALS) and Frontotemporal lobar dementia (FTLD): Thursday, October 28, 2010
| No 1 | Eva Bentmann et al. DZNE & University of Munich ALS-associated FUS mutations disrupt transportin-mediated nuclear import |
| No 2 | Carola Stribl et al. Helmholtz Center Munich Generation of a mouse model for FTLD and ALS |
Topic 2: APP processing and function: Thursday, October 28, 2010
| No 3 | Veit Althoff (Breuer Stipend) et al. Free University of Berlin Purification and characterization of APP C100 FAD mutants and cystein-linked APP dimers |
| No 4 | Susanne Bürger (Breuer Stipend) et al. University of Leipzig Inhibition of VEGF signaling differentially alters processing of APP in primary cultured neurons, astrocytes and endothelial cells |
| No 5 | Peer-Hendrik Kuhn et al. DZNE & University of Munich ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons |
| No 6 | Daniel Fleck (Breuer Stipend) et al. DZNE & University of Munich Investigation of Bace1 expression and localization in health and Alzheimer's disease |
| No 7 | Akio Fukumori et al. DZNE & University of Munich Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intra-membrane proteolysis |
Topic 3: Aggregation and toxicity: Thursday, October 28, 2010
| No 8 | Jens Moreth1, Katja Kroker1, Daniel Schwanzar2, Lothar Kussmaul1 Boehringer Ingelheim Pharma GmbH & Co KG1, Biberach and University Hospital - Experimental Neurology2, Ulm Aß aggregates bind to neurons and affect neurotransmission by different ways |
| No 9 | Hans Zempel, Edda Thies, Eckhard Mandelkow, Eva-Maria Mandelkow MPI for Struct. Mol. Biol., Hamburg & DZNE Bonn Abeta oligomers cause localized Ca++ elevation, missorting of endogenous tau into dendrites, tau phosphorylation, and destruction of microtubules and spines |
| No 10 | Christian Jung et al. University of Munich The role of presenilin1 in dendritic spine plasticity |
| No 11 | Nambirajan Govindarajan (Breuer Stipend) et al. European Neuroscience Institute, Göttingen Loss of HDAC6 attenuates the pathogenesis of Alzheimer´s Disease |
| No 12 | Gwendolyn Behrendt et al. University of Munich The role of myelin repair and stem cell dedifferentiation in Alzheimer`s disease in mice and men |
Topic 4: Therapeutic targets: Friday, October 29, 2010
| No 13 | Frauke van Bebber et al. DZNE & University of Munich Zebrafish BACE1 knock- down phenotype provides an in vivo assay for BACE inhibitor development |
| No 14 | Sabine Liebscher et al. DZNE & University of Munich Effects of chronic γ-secretase inhibition in an APP/PS1 transgenic mouse model of Alzheimer’s Disease |
| No 15 | Benedikt Kretner, Richard Page et al. DZNE & University of Munich Pharmacological modulation of gamma-secretase |
Topic 5: Parkinson´s disease and prion disorders: Friday, October 29, 2010
| No 16 | Nicole Exner et al. DZNE & University of Munich Alpha-synuclein inhibits membrane fusion |
| No 17 | Pontus Klein et al. MPI of Neurobiology, Munich Functional interactions of GDNF/Ret signaling and Parkinson-associated genes parkin and pink1 |
| No 18 | Barbara Solchenberger et al. DZNE & University of Munich Biochemical and phenotypical characterization of alpha-synuclein transgenic zebrafish |
| No 19 | Petra Frick et al. University of Munich Protein misfolding cyclic amplification as a tool to characterize sporadic Creutzfeldt-Jakob disease strains and their transmission properties |
| No 20 | Julia Hofmann et al. DZNE Bonn Natural transmission of cytosolic prions within mammalian cell populations |
| No 21 | Ulrike Resenberger et al. DZNE & University of Munich Cellular prion protein mediates toxic signaling of Aß oligomers |