Eibsee Meeting

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Poster Session

Topic 1: Amyotrophic lateral sclerosis (ALS) and Frontotemporal lobar dementia (FTLD): Thursday, October 28, 2010

No 1 Eva Bentmann et al.
DZNE & University of Munich

ALS-associated FUS mutations disrupt transportin-mediated nuclear import
No 2 Carola Stribl et al.
Helmholtz Center Munich

Generation of a mouse model for FTLD and ALS

Topic 2: APP processing and function: Thursday, October 28, 2010

No 3 Veit Althoff (Breuer Stipend) et al.
Free University of Berlin

Purification and characterization of APP C100 FAD mutants and cystein-linked APP dimers
No 4 Susanne Bürger (Breuer Stipend) et al.
University of Leipzig

Inhibition of VEGF signaling differentially alters processing of APP in primary cultured neurons, astrocytes and endothelial cells
No 5 Peer-Hendrik Kuhn et al.
DZNE & University of Munich

ADAM10 is the physiologically relevant, constitutive alpha-secretase of the amyloid precursor protein in primary neurons
No 6 Daniel Fleck (Breuer Stipend) et al.
DZNE & University of Munich

Investigation of Bace1 expression and localization in health and Alzheimer's disease
No 7 Akio Fukumori et al.
DZNE & University of Munich

Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intra-membrane proteolysis


Topic 3: Aggregation and toxicity: Thursday, October 28, 2010

No 8 Jens Moreth1, Katja Kroker1, Daniel Schwanzar2, Lothar Kussmaul1
Boehringer Ingelheim Pharma GmbH & Co KG1, Biberach and University Hospital - Experimental Neurology2, Ulm

Aß aggregates bind to neurons and affect neurotransmission by different ways
No 9 Hans Zempel, Edda Thies, Eckhard Mandelkow, Eva-Maria Mandelkow
MPI for Struct. Mol. Biol., Hamburg & DZNE Bonn

Abeta oligomers cause localized Ca++ elevation, missorting of endogenous tau into dendrites, tau phosphorylation, and destruction of microtubules and spines
No 10 Christian Jung et al.
University of Munich

The role of presenilin1 in dendritic spine plasticity
No 11 Nambirajan Govindarajan (Breuer Stipend) et al.
European Neuroscience Institute, Göttingen

Loss of HDAC6 attenuates the pathogenesis of Alzheimer´s Disease
No 12 Gwendolyn Behrendt et al.
University of Munich

The role of myelin repair and stem cell dedifferentiation in Alzheimer`s disease in mice and men


Topic 4: Therapeutic targets: Friday, October 29, 2010

No 13 Frauke van Bebber et al.
DZNE & University of Munich

Zebrafish BACE1 knock- down phenotype provides an in vivo assay for BACE inhibitor development
No 14 Sabine Liebscher et al.
DZNE & University of Munich

Effects of chronic γ-secretase inhibition in an APP/PS1 transgenic mouse model of Alzheimer’s Disease
No 15 Benedikt Kretner, Richard Page et al.
DZNE & University of Munich

Pharmacological modulation of gamma-secretase


Topic 5: Parkinson´s disease and prion disorders: Friday, October 29, 2010

No 16 Nicole Exner et al.
DZNE & University of Munich

Alpha-synuclein inhibits membrane fusion
No 17 Pontus Klein et al.
MPI of Neurobiology, Munich

Functional interactions of GDNF/Ret signaling and Parkinson-associated genes parkin and pink1
No 18 Barbara Solchenberger et al.
DZNE & University of Munich

Biochemical and phenotypical characterization of alpha-synuclein transgenic zebrafish
No 19 Petra Frick et al.
University of Munich

Protein misfolding cyclic amplification as a tool to characterize sporadic Creutzfeldt-Jakob disease strains and their transmission properties
No 20 Julia Hofmann et al.

Natural transmission of cytosolic prions within mammalian cell populations
No 21 Ulrike Resenberger et al.
DZNE & University of Munich

Cellular prion protein mediates toxic signaling of Aß oligomers

Responsible for content: Prof. Dr. Dr. h.c. Christian Haass