Eibsee Meeting

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Wednesday, October 29 - Arrival, Hiking, Opening Lecture

Time Description
15:00 The traditional “Scientific walk“ around the lake (if weather permits)
17:00 - 17:15

C. Haass, University of Munich, Germany

17:15 - 18:15

Key Note Lecture
T. Golde, Mayo Clinic, Jacksonville, USA
Substrate targeting gamma-secretase modulators


sponsored by the Hans und Ilse Breuer Foundation

19:00 Dinner


Thursday, October 30 - Secretases I

Chair: E. Mandelkow

Time Description
09:00 - 09:25 B. de Strooper, VIB and K.U. Leuven, Belgium

Heterogeneity of the γ-secretase complex opens new avenues to therapy

09:25 - 09:50 H. Li, Brookhaven National Laboratory, Upton, USA

Cryo-EM structural characterization of γ-secretase

09:50 - 10:15 H. Steiner, University of Munich, Germany

Functional and structural analysis of γ-secretase

10:15 - 10:40 G. Multhaup, University of Berlin, Germany

Molecular dissection of substrate-secretase interactions

10:40 - 11:20 Coffee Break/Poster Session: APP trafficking & processing
11:20 - 11:45 C. Kaether, Leibniz Institute for Age Research, Jena, Germany

Quality control of gamma-secretase assembly in the ER

11:45 - 12:10 J. Walter, University of Bonn, Germany

Lipid-dependent metabolism of the amyloid beta-peptide

12:10 - 12:35 T. Hartmann, University of the Saarland, Homburg, Germany

Sterol and glycosphingolipid regulation of γ-secretase

12:35 - 13:00 R. Fluhrer, University of Munich, Germany

Insight into the cleavage mechanisms of GxGD-type aspartylproteases

13:00 - 14:00 Lunch
14:00 - 15:00 Time for recreation (hiking, swimming, sauna)


Thursday, October 30 - Secretases II

Chair: U. Müller

Time Description
15:00 – 15:25 R. Vassar, Northwestern University, Chicago, USA

The role of BACE1 in Alzheimer´s disease

15:25 – 15:50 P. Wong, The Johns Hopkins University, Baltimore, USA

Moderate inhibition of both BACE1 and γ-secretase: towards a safe and effective Alzheimer's therapy

15:50 – 16:15 M. Willem, University of Munich, Germany

The good and the bad side of BACE1

16:15 – 16:40 S. Lichtenthaler, University of Munich, Germany

Secretase inhibitors and modulators in Alzheimer´s disease

16:40 – 17:20 Coffee Break/Poster Session: APP trafficking & processing


Thursday, October 30 - Secretases II

Chair: T. Hartmann

Time Description
17:20 – 17:45 P. Saftig, University of Kiel, Germany

Function and regulation of ADAM proteases

17:45 – 18:10 F. Fahrenholz, University of Mainz, Germany

Transcriptional activation of the α-secretase ADAM10 via nuclear receptors

18:10 – 18:35 S. Lammich, University of Munich, Germany

Post-transcriptional regulation of the a-secretase ADAM10

19:00 Dinner


Friday, October 31 - APP function and transport

Chair: H. Steiner

Time Description
9:00 – 9:25 T. Willnow, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany

SORLA - a receptor to sort out APP processing

9:25 – 9:50  S. Kins, University of Heidelberg, Germany

Subcellular traffic of APP family members in neurons

9:50 – 10:15 U. Müller, University of Heidelberg, Germany

Progress on APP/APLP physiology

10:15 – 10:55 Coffee Break/Poster Session: Aggregation, Toxicity, Aging


Friday, October 31 - Oligomers and Aggregation

Chair: G. Multhaup

Time Description
10:55 – 11:20 E.M. Mandelkow, Max-Planck-Unit for Structural Molecular Biology, Hamburg, Germany

Inducible tau-transgenic mice: Lessons on phosphorylation, aggregation, and behaviour

11:20 – 11:45   E. Mandelkow, Max-Planck-Unit for Structural Molecular Biology, Hamburg, Germany

From Tau structure to aggregation inhibitors

11:45 – 12:10 G. Shankar, Harvard Medical School, Boston, USA
Amyloid ß-protein dimers isolated directly from Alzheimer brains impair synaptic plasticity and memory 
12:30 – 14:00 Lunch
14:00 – 15:00 Time for recreation (hiking, swimming, sauna)


Friday, October 31 - Drug Development & Therapy

Chair: S. Lichtenthaler

Time Description
15:00 – 15:25 G. Basi, Elan, San Francisco, USA
Immunotherapy at atomic resolution
15:25 – 15:50 S. Roßner, University of Leipzig, Germany
Inhibition of glutaminyl cyclase – a novel concept for the treatment of Alzheimer´s disease


Friday, October 31 - Neuronal Toxicity and Regeneration

Chair: F. Fahrenholz

Time Description
15:50 – 16:15 M. Meyer-Luehmann, Harvard Medical School, Charlestown, USA
Cascade of pathogenic events in Alzheimer´s disease: insights from mouse models
16:15 – 16:40 J. Herms, University of Munich, Germany
Dystrophic dendrites in neurodegenerative diseases: cause or consequence of synaptic failure?
16:40 – 17:20 Coffee Break/Poster Session: PD & other neurodegenerative diseases
17:20 – 17:45 M. Jucker, University of Tübingen, Germany
Mikroglia ablation in APP transgenic mice
17:45 – 18:10 O. Garaschuk, Technical University of Munich, Germany
Impaired cortical network function in Alzheimer’s disease: the role of microglia
18:10 – 18:35 A. Fischer, European Neuroscience Institute, Göttingen, Germany
Deregulation of epigenetic processes during aging and neurodegeneration
18:35 – 19:00 J. Tatzelt, University of Munich, Germany
Stress-protective signalling of PrPC is linked to dimer formation and corrupted by PrPSc
19:00 Dinner

Saturday, November 1 - Departure