Program
- Program ( 479 KB )
Wednesday, October 29 - Arrival, Hiking, Opening Lecture
| Time | Description |
|---|---|
| 15:00 | The traditional “Scientific walk“ around the lake (if weather permits) |
| 17:00 - 17:15 |
Welcome |
| 17:15 - 18:15 |
Key Note Lecture |
| 18:15 |
Cocktails |
| 19:00 | Dinner |
Thursday, October 30 - Secretases I
Chair: E. Mandelkow
| Time | Description |
|---|---|
| 09:00 - 09:25 |
B. de Strooper, VIB and K.U. Leuven, Belgium
Heterogeneity of the γ-secretase complex opens new avenues to therapy |
| 09:25 - 09:50 |
H. Li, Brookhaven National Laboratory, Upton, USA
Cryo-EM structural characterization of γ-secretase |
| 09:50 - 10:15 |
H. Steiner, University of Munich, Germany
Functional and structural analysis of γ-secretase |
| 10:15 - 10:40 |
G. Multhaup, University of Berlin, Germany
Molecular dissection of substrate-secretase interactions |
| 10:40 - 11:20 | Coffee Break/Poster Session: APP trafficking & processing |
| 11:20 - 11:45 |
C. Kaether, Leibniz Institute for Age Research, Jena, Germany
Quality control of gamma-secretase assembly in the ER |
| 11:45 - 12:10 |
J. Walter, University of Bonn, Germany
Lipid-dependent metabolism of the amyloid beta-peptide |
| 12:10 - 12:35 |
T. Hartmann, University of the Saarland, Homburg, Germany
Sterol and glycosphingolipid regulation of γ-secretase |
| 12:35 - 13:00 |
R. Fluhrer, University of Munich, Germany
Insight into the cleavage mechanisms of GxGD-type aspartylproteases |
| 13:00 - 14:00 | Lunch |
| 14:00 - 15:00 | Time for recreation (hiking, swimming, sauna) |
Thursday, October 30 - Secretases II
Chair: U. Müller
| Time | Description |
|---|---|
| 15:00 – 15:25 |
R. Vassar, Northwestern University, Chicago, USA
The role of BACE1 in Alzheimer´s disease |
| 15:25 – 15:50 |
P. Wong, The Johns Hopkins University, Baltimore, USA
Moderate inhibition of both BACE1 and γ-secretase: towards a safe and effective Alzheimer's therapy |
| 15:50 – 16:15 |
M. Willem, University of Munich, Germany
The good and the bad side of BACE1 |
| 16:15 – 16:40 |
S. Lichtenthaler, University of Munich, Germany
Secretase inhibitors and modulators in Alzheimer´s disease |
| 16:40 – 17:20 | Coffee Break/Poster Session: APP trafficking & processing |
Thursday, October 30 - Secretases II
Chair: T. Hartmann
| Time | Description |
|---|---|
| 17:20 – 17:45 |
P. Saftig, University of Kiel, Germany
Function and regulation of ADAM proteases |
| 17:45 – 18:10 |
F. Fahrenholz, University of Mainz, Germany
Transcriptional activation of the α-secretase ADAM10 via nuclear receptors |
| 18:10 – 18:35 |
S. Lammich, University of Munich, Germany
Post-transcriptional regulation of the a-secretase ADAM10 |
| 19:00 | Dinner |
Friday, October 31 - APP function and transport
Chair: H. Steiner
| Time | Description |
|---|---|
| 9:00 – 9:25 |
T. Willnow, Max-Delbrück-Center for Molecular Medicine, Berlin, Germany
SORLA - a receptor to sort out APP processing |
| 9:25 – 9:50 |
S. Kins, University of Heidelberg, Germany
Subcellular traffic of APP family members in neurons |
| 9:50 – 10:15 |
U. Müller, University of Heidelberg, Germany
Progress on APP/APLP physiology |
| 10:15 – 10:55 | Coffee Break/Poster Session: Aggregation, Toxicity, Aging |
Friday, October 31 - Oligomers and Aggregation
Chair: G. Multhaup
| Time | Description |
|---|---|
| 10:55 – 11:20 |
E.M. Mandelkow, Max-Planck-Unit for Structural Molecular Biology, Hamburg, Germany
Inducible tau-transgenic mice: Lessons on phosphorylation, aggregation, and behaviour |
| 11:20 – 11:45 |
E. Mandelkow, Max-Planck-Unit for Structural Molecular Biology, Hamburg, Germany
From Tau structure to aggregation inhibitors |
| 11:45 – 12:10 | G. Shankar, Harvard Medical School, Boston, USA Amyloid ß-protein dimers isolated directly from Alzheimer brains impair synaptic plasticity and memory |
| 12:30 – 14:00 | Lunch |
| 14:00 – 15:00 | Time for recreation (hiking, swimming, sauna) |
Friday, October 31 - Drug Development & Therapy
Chair: S. Lichtenthaler
| Time | Description |
|---|---|
| 15:00 – 15:25 | G. Basi, Elan, San Francisco, USA Immunotherapy at atomic resolution |
| 15:25 – 15:50 | S. Roßner, University of Leipzig, Germany Inhibition of glutaminyl cyclase – a novel concept for the treatment of Alzheimer´s disease |
Friday, October 31 - Neuronal Toxicity and Regeneration
Chair: F. Fahrenholz
| Time | Description |
|---|---|
| 15:50 – 16:15 | M. Meyer-Luehmann, Harvard Medical School, Charlestown, USA Cascade of pathogenic events in Alzheimer´s disease: insights from mouse models |
| 16:15 – 16:40 | J. Herms, University of Munich, Germany Dystrophic dendrites in neurodegenerative diseases: cause or consequence of synaptic failure? |
| 16:40 – 17:20 | Coffee Break/Poster Session: PD & other neurodegenerative diseases |
| 17:20 – 17:45 | M. Jucker, University of Tübingen, Germany Mikroglia ablation in APP transgenic mice |
| 17:45 – 18:10 | O. Garaschuk, Technical University of Munich, Germany Impaired cortical network function in Alzheimer’s disease: the role of microglia |
| 18:10 – 18:35 | A. Fischer, European Neuroscience Institute, Göttingen, Germany Deregulation of epigenetic processes during aging and neurodegeneration |
| 18:35 – 19:00 | J. Tatzelt, University of Munich, Germany Stress-protective signalling of PrPC is linked to dimer formation and corrupted by PrPSc |
| 19:00 | Dinner |